Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2271697 | 0.86 | RAB9A (0.45) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2271723 | 0.77 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL23628970 | 0.76 | SMN1; SMN2 (0.54) | MAPK14KDM4ENPC1RAB9ALMNA | |
| SCHEMBL2273200 | 0.76 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL2273344 | 0.76 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL17801241 | 0.75 | CCNA2 (0.39) | MAPK14KDM4ECCNA2CDK2PTP4A3 | |
| SCHEMBL4499710 | 0.75 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL4500018 | 0.73 | NPC1 (0.47) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL21062055 | 0.72 | HCAR3 (0.46) | MAPK14KDM4ECCNA2CDK2LMNA | |
| SCHEMBL9963507 | 0.69 | NPC1 (0.45) | NPC1RAB9ALMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910348-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |