Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73741 | 0.83 | RAB9A (0.62) | KDM4EGAAMAPTHPGDLMNA | |
| SCHEMBL31716343 | 0.83 | LDHA (0.56) | KDM4EGAAMAPTLMNAHSD17B10 | |
| SCHEMBL3592563 | 0.83 | KDM4E (0.50) | KDM4EGAAMAPTNFKB1HPGD | |
| SCHEMBL2275594 | 0.82 | RAB9A (0.54) | GAAMAPTNFKB1HPGDLMNA | |
| Hydrochloric Acid SCHEMBL3592885 | 0.81 | RAB9A (0.60) | KDM4EGAAMAPTHPGDLMNA | |
| SCHEMBL12596891 | 0.80 | KDM4E (0.79) | KDM4EGAAMAPTNFKB1HPGD | |
| SCHEMBL14684919 | 0.80 | NPC1 (0.56) | KDM4EMAPTNFKB1HPGDLMNA | |
| SCHEMBL7407979 | 0.80 | APP (0.54) | GAAMAPTHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL8038269 | 0.79 | KDM4E (0.57) | KDM4EGAAMAPTNFKB1LMNA | |
| SCHEMBL10973241 | 0.78 | CA2 (0.63) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910348-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016392-A2 | BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |