Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 12/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197025 | 0.81 | SLC6A7 (0.55) | SLC6A7SLC6A3TAAR1KDM4EALDH1A1 | |
| SCHEMBL3581805 | 0.77 | SLC6A7 (0.58) | SLC6A7SLC6A3PDE4A | |
| SCHEMBL3572446 | 0.77 | SLC6A7 (0.70) | SLC6A7SLC6A3 | |
| SCHEMBL13780807 | 0.70 | SLC6A7 (0.46) | SLC6A7SLC6A3TAAR1KDM4EALDH1A1 | |
| SCHEMBL14175664 | 0.64 | SLC6A7 (0.58) | SLC6A7SLC6A3ALDH1A1 | |
| SCHEMBL19190790 | 0.64 | POLB (0.51) | TAAR1MAOBGRM2 | |
| SCHEMBL16394285 | 0.63 | TAAR1 (0.71) | TAAR1MAOB | |
| SCHEMBL31491189 | 0.63 | TAAR1 (0.71) | TAAR1MAOB | |
| SCHEMBL3585163 | 0.63 | SLC6A7 (0.56) | SLC6A7SLC6A3PDE4A | |
| SCHEMBL1135093 | 0.63 | SLC6A7 (0.68) | SLC6A7SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006124748-A2 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON GENETICS INCORPORATED (US) | 2006-11-23 | — | — | WO | claimed |