SCHEMBL4695754

SCHEMBL4695754

Cc1ccc(NC(=O)CCN2CC3CN(C(=O)c4cc(F)cc(C(F)(F)F)c4)CC3C2)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.46
CYP3A4 P08684 3/20 0.46
CYP2C19 P33261 3/20 0.46
CYP2C9 P11712 2/20 0.46
RXFP1 Q9HBX9 1/20 0.44
CHRM4 P08173 1/20 0.43
CHRM1 P11229 1/20 0.43
CYP2D6 P10635 2/20 0.43
TERT O14746 1/20 0.43
BLM P54132 1/20 0.42
RHOC P08134 4/20 0.42
RHOA P61586 4/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 2/20 0.41
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4690840 0.90 NPY2R (0.49) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4694150 0.89 NPY2R (0.51) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4695756 0.87 RHOA (0.41) CYP1A2CYP3A4CYP2C19RXFP1CHRM4
SCHEMBL4691227 0.85 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4691875 0.85 CYP3A4 (0.46) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4694813 0.84 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C19CYP2C9BLM
SCHEMBL4693167 0.83 HCRTR1 (0.50) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4692104 0.83 HCRTR1 (0.50) CYP1A2CYP3A4CYP2C19CYP2C9RXFP1
SCHEMBL4694236 0.82 EPHX2 (0.44) CYP1A2CYP3A4CYP2C19CYP2C9MEN1
SCHEMBL4694785 0.82 KMT2A (0.48) CYP1A2CYP3A4CYP2C19CYP2C9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed