SCHEMBL4694150

SCHEMBL4694150

Cc1ccc(NC(=O)CCN2CC3CN(C(=O)c4cccc(C(F)(F)F)c4)CC3C2)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPY2R P49146 1/20 0.51
CHRM4 P08173 1/20 0.50
CHRM5 P08912 1/20 0.50
CHRM1 P11229 1/20 0.50
CHRM3 P20309 1/20 0.50
SMN1; SMN2 Q16637 4/20 0.48
ALDH1A1 P00352 3/20 0.48
CYP2C9 P11712 2/20 0.48
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C19 P33261 2/20 0.48
POLB P06746 2/20 0.48
TSHR P16473 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CSF1R P07333 1/20 0.46
PDGFRB P09619 1/20 0.46
KIT P10721 1/20 0.46
DDR1 Q08345 1/20 0.46
RXFP1 Q9HBX9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4690840 0.90 NPY2R (0.49) NPY2RCHRM4CHRM1CYP2C9CYP1A2
SCHEMBL4695754 0.89 CYP1A2 (0.46) CHRM4CHRM1SMN1; SMN2ALDH1A1CYP2C9
SCHEMBL4694155 0.87 NPY2R (0.48) NPY2RCHRM4CHRM5CHRM1CHRM3
SCHEMBL4691875 0.85 CYP3A4 (0.46) CHRM1ALDH1A1CYP2C9CYP1A2CYP3A4
SCHEMBL4691227 0.85 CYP1A2 (0.46) ALDH1A1CYP2C9CYP1A2CYP3A4CYP2C19
SCHEMBL4693609 0.85 SMN1; SMN2 (0.52) NPY2RSMN1; SMN2ALDH1A1POLBNPSR1
SCHEMBL4695950 0.85 TERT (0.45) SMN1; SMN2ALDH1A1CYP2C9CYP1A2CYP3A4
SCHEMBL4694022 0.84 P2RX7 (0.47) NPY2RKMT2A
SCHEMBL3281859 0.84 CCR5 (0.52) SMN1; SMN2ALDH1A1TSHRLMNAKMT2A
SCHEMBL4693012 0.83 NPY2R (0.51) NPY2RSMN1; SMN2POLBLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed