Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689950 | 0.86 | CRHBP (0.49) | F2KMT2ARAB9AHIF1A | |
| SCHEMBL4689485 | 0.85 | CSNK1E (0.50) | F2MAPTSMN1; SMN2CSNK1EHTT | |
| SCHEMBL4692605 | 0.85 | HTT (0.50) | F2ALDH1A1MAPTCSNK1EMAPK1 | |
| SCHEMBL3350556 | 0.83 | ANPEP (0.53) | F2ALDH1A1LTA4HKMT2ASMN1; SMN2 | |
| SCHEMBL4694780 | 0.82 | CSNK1E (0.44) | F2ALDH1A1MAPTKMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5219618 | 0.82 | ANPEP (0.52) | F2ALDH1A1LTA4HKMT2ARAB9A | |
| SCHEMBL4694821 | 0.81 | F2 (0.51) | F2ALDH1A1MAPTLTA4HRAB9A | |
| SCHEMBL4692213 | 0.81 | CSNK1E (0.45) | F2ALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL3349155 | 0.81 | KDM4E (0.58) | ALDH1A1LTA4HKMT2ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL5219220 | 0.80 | ANPEP (0.57) | ALDH1A1LTA4HKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |