Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689485 | 0.85 | CSNK1E (0.50) | CSNK1EMAPTSMN1; SMN2F2SLC15A1 | |
| SCHEMBL4692605 | 0.85 | HTT (0.50) | CSNK1EALDH1A1MAPTMAPK1F2 | |
| SCHEMBL4694780 | 0.82 | CSNK1E (0.44) | CSNK1EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4695907 | 0.81 | F2 (0.47) | CSNK1EALDH1A1MAPTRAB9AMAPK1 | |
| SCHEMBL23093131 | 0.77 | SLC6A4 (0.52) | CSNK1ENPC1RAB9AKMT2AF2 | |
| SCHEMBL23092416 | 0.77 | SLC6A4 (0.52) | CSNK1ENPC1RAB9AKMT2AF2 | |
| SCHEMBL23092415 | 0.77 | SLC6A4 (0.52) | CSNK1ENPC1RAB9AKMT2AF2 | |
| SCHEMBL4695052 | 0.76 | ALDH1A1 (0.45) | CSNK1EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4307947 | 0.75 | BACE1 (0.53) | — | |
| SCHEMBL14416465 | 0.75 | CSNK1E (0.55) | CSNK1EF2SLC15A1MAOAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |