Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LAP3 | P28838 | 3/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689485 | 0.89 | CSNK1E (0.50) | HTTCSNK1EF2SLC15A1EPHX1 | |
| SCHEMBL4694780 | 0.85 | CSNK1E (0.44) | HTTCSNK1EF2SLC15A1NPSR1 | |
| SCHEMBL4695052 | 0.85 | ALDH1A1 (0.45) | HTTCSNK1EF2TACR1NPSR1 | |
| SCHEMBL4695907 | 0.85 | F2 (0.47) | HTTCSNK1EF2MAPK1ALDH1A1 | |
| SCHEMBL4692213 | 0.85 | CSNK1E (0.45) | CSNK1EF2SLC15A1MAPK1EPHX1 | |
| SCHEMBL8130009 | 0.84 | HTT (0.56) | HTTTACR1EPHX1ANPEPSLC6A2 | |
| SCHEMBL3349267 | 0.81 | BCHE (0.53) | CSNK1EF2ALDH1A1ANPEPCYP1A2 | |
| SCHEMBL23092416 | 0.81 | SLC6A4 (0.52) | CSNK1EF2SLC15A1EPHX1MAOA | |
| SCHEMBL23093131 | 0.81 | SLC6A4 (0.52) | CSNK1EF2SLC15A1EPHX1MAOA | |
| SCHEMBL23092415 | 0.81 | SLC6A4 (0.52) | CSNK1EF2SLC15A1EPHX1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |