Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16685781 | 0.76 | CYP2D6 (0.39) | CYP2D6CYP2C19HTR2CCYP1A2CYP2C9 | |
| SCHEMBL832390 | 0.69 | MAOA (0.47) | CYP2D6CYP2C19CYP1A2IGF1RALDH1A1 | |
| SCHEMBL2419272 | 0.68 | POLB (0.44) | CYP1A2ALDH1A1KMT2A | |
| SCHEMBL32686267 | 0.68 | HTR2C (0.36) | CYP2D6CYP2C19HTR2CCYP1A2CYP2C9 | |
| SCHEMBL22446422 | 0.67 | LMNA (0.43) | CYP2D6CYP2C19CYP1A2CYP2C9CHEK1 | |
| SCHEMBL8141883 | 0.67 | ACHE (0.40) | CYP2D6CYP2C19CYP1A2CYP2C9ALK | |
| SCHEMBL11347720 | 0.67 | KDM4E (0.40) | CYP2C19CYP2C9LMNAALDH1A1MAPT | |
| SCHEMBL11555797 | 0.66 | CYP2A6 (0.34) | ALDH1A1 | |
| SCHEMBL31221719 | 0.66 | CAMKK1 (0.38) | CYP2D6CYP2C19HTR2CCYP1A2CYP2C9 | |
| SCHEMBL29244675 | 0.66 | CYP2D6 (0.37) | CYP2D6CYP2C19HTR2CCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937673-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045339-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (DE) | 2007-04-26 | — | — | WO | disclosed |