Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CRHBP | P24387 | 3/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5285266 | 0.80 | ALDH1A1 (0.45) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL2148173 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL1532324 | 0.77 | ALDH1A1 (0.58) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL29182467 | 0.76 | ALDH1A1 (0.57) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL7821980 | 0.76 | ALDH1A1 (0.52) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL11844609 | 0.75 | ALDH1A1 (0.56) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL8977870 | 0.74 | MAPT (0.53) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL3397567 | 0.74 | ALDH1A1 (0.65) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 | |
| SCHEMBL20582642 | 0.73 | CRHBP (0.53) | ALDH1A1CRHBPCRHR2TDP1SMN1; SMN2 | |
| SCHEMBL29667979 | 0.73 | ALDH1A1 (0.51) | ALDH1A1CRHBPCRHR2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115260211-B | Thiophene condensed ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115260211-A | Thiophene fused ring containing derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |
| EP-1957487-A1 | NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES | AEterna Zentaris GmbH (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007054556-A1 | NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES | ÆTERNA ZENTARIS GMBH (DE) | 2007-05-18 | — | — | WO | disclosed |
| EP-1785423-A1 | Pyridopyrazine derivatives and their use as kinase modulators | Zentaris GmbH (DE) | 2007-05-16 | — | — | EP | disclosed |