Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | RAB7A | P51149 | 4/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CDC42 | P60953 | 1/20 | 0.46 |
| ▸ | RAB2A | P61019 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15281315 | 0.78 | ALDH1A1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL21247198 | 0.68 | ALDH1A1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8288608 | 0.65 | KMT2A (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15832859 | 0.65 | RAB7A (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL21260779 | 0.63 | ALDH1A1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15272485 | 0.61 | KDM4E (0.72) | SMN1; SMN2ALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL14825265 | 0.61 | CFTR (0.80) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2643514 | 0.61 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL618553 | 0.60 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2643860 | 0.60 | GCGR (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620425-B1 | SUBSTITUTED 3-CYANOTHIOPHENE ACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | claimed |