Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.63 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787493 | 0.81 | FBP1 (0.64) | FBP1KDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL1787490 | 0.81 | FBP1 (0.64) | FBP1KDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL1237311 | 0.80 | FBP1 (0.69) | FBP1GLO1KDM4EALDH1A1 | |
| SCHEMBL1237309 | 0.80 | FBP1 (0.69) | FBP1GLO1KDM4EALDH1A1 | |
| SCHEMBL30295762 | 0.78 | FBP1 (1.00) | FBP1KDM4EALDH1A1KMT2A | |
| SCHEMBL630963 | 0.78 | FBP1 (1.00) | FBP1KDM4EALDH1A1KMT2A | |
| SCHEMBL525207 | 0.78 | FBP1 (1.00) | FBP1KDM4EALDH1A1KMT2A | |
| SCHEMBL630964 | 0.78 | FBP1 (1.00) | FBP1KDM4EALDH1A1KMT2A | |
| SCHEMBL28479114 | 0.76 | FBP1 (0.69) | FBP1KMT2A | |
| SCHEMBL4212118 | 0.75 | BCL2 (0.43) | HDAC4MEF2DKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079861-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |