SCHEMBL1237309

SCHEMBL1237309

Cc1cccc(/C=C(\Cl)[N+](=O)[O-])c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 11/20 0.69
TSHR P16473 1/20 0.44
ACHE P22303 1/20 0.44
NPC1 O15118 2/20 0.43
HSP90AA1 P07900 1/20 0.43
RAB9A P51151 1/20 0.43
ATM Q13315 1/20 0.43
TP53 P04637 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
POLB P06746 1/20 0.43
MAPT P10636 1/20 0.43
GLO1 Q04760 1/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1237311 1.00 FBP1 (0.69) FBP1TSHRACHENPC1HSP90AA1
SCHEMBL525207 0.81 FBP1 (1.00) FBP1NPC1HSP90AA1RAB9ATDP1
SCHEMBL14230254 0.81 FBP1 (0.66) FBP1TSHRACHENPC1HSP90AA1
SCHEMBL630964 0.81 FBP1 (1.00) FBP1NPC1HSP90AA1RAB9ATDP1
SCHEMBL630963 0.81 FBP1 (1.00) FBP1NPC1HSP90AA1RAB9ATDP1
SCHEMBL30295762 0.81 FBP1 (1.00) FBP1NPC1HSP90AA1RAB9ATDP1
SCHEMBL28479114 0.80 FBP1 (0.69) FBP1NPC1RAB9APOLBCYP1A2
SCHEMBL29248030 0.80 FBP1 (0.54) FBP1TSHRACHENPC1HSP90AA1
SCHEMBL29248035 0.80 FBP1 (0.54) FBP1TSHRACHENPC1HSP90AA1
SCHEMBL4696757 0.80 FBP1 (0.63) FBP1KDM4EALDH1A1GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8476309-B2 Benzofuran cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-07-02 US disclosed
US-8476309-B2 Benzofuran cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-07-02 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-8431595-B2 Furanopyridine cannabinoid compounds and related methods of use THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2013-04-30 US disclosed
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-02-24 US disclosed
WO-2011022694-A2 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022692-A2 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed
WO-2011022679-A2 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2011-02-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046176-A1 FURANOPYRIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, FAAH FBP1 481/4885TSHR 1591/4885ACHE 1069/4885
US-20110046175-A1 BENZOFURAN CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, GPR18 FBP1 561/4885TSHR 2189/4885ACHE 2166/4885
US-20110046163-A1 FURANOPYRIMIDINE CANNABINOID COMPOUNDS AND RELATED METHODS OF USE CNR1, CNR2, GPR17 FBP1 306/4885TSHR 1874/4885ACHE 2398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.