Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 16/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.41 |
| ▸ | PDE2A | O00408 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698585 | 0.90 | HSD11B1 (0.53) | HSD11B1PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL4698838 | 0.84 | HSD11B1 (0.60) | HSD11B1MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL4699066 | 0.84 | HSD11B1 (0.50) | HSD11B1PDE3BPDE3AP2RY12MEN1 | |
| Hydrochloric Acid SCHEMBL4698625 | 0.83 | HSD11B1 (0.49) | HSD11B1PDE3BPDE3AP2RY12MEN1 | |
| SCHEMBL4697372 | 0.83 | HSD11B1 (0.51) | HSD11B1PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL4696609 | 0.82 | HSD11B1 (0.57) | HSD11B1MEN1KMT2AALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5103842 | 0.82 | HSD11B1 (0.50) | HSD11B1PDE3BPDE3AMEN1KMT2A | |
| SCHEMBL4698927 | 0.82 | HSD11B1 (0.52) | HSD11B1HRH3 | |
| SCHEMBL2998771 | 0.81 | HSD11B1 (0.41) | HSD11B1PDE3BPDE3AP2RY12PDE2A | |
| Hydrochloric Acid SCHEMBL4698062 | 0.81 | HSD11B1 (0.51) | HSD11B1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214621-A1 | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 | ELI LILLY AND COMPANY | 2008-09-04 | — | — | US | disclosed |
| EP-1830841-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214621-A1 | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885PDE3B 870/4885PDE3A 992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.