Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464670 | 0.90 | POLB (0.51) | ADRB1HTR6CHRM1DRD2DRD4 | |
| SCHEMBL3324240 | 0.81 | HTR6 (0.60) | ADRB1HTR6HTR3EHTR3BHTR3A | |
| SCHEMBL4493695 | 0.80 | HDAC1 (0.54) | ADRB1HTR6HTR3EHTR3BHTR3A | |
| SCHEMBL4480619 | 0.80 | POLB (0.49) | ADRB1HTR6CHRM1DRD2DRD4 | |
| SCHEMBL29173745 | 0.79 | CMA1 (0.54) | — | |
| SCHEMBL4475770 | 0.79 | DRD2 (0.55) | ADRB1CHRM1DRD2DRD4DRD3 | |
| SCHEMBL4483596 | 0.77 | POLB (0.53) | ADRB1HTR6CHRM1DRD2DRD4 | |
| SCHEMBL4477885 | 0.75 | L3MBTL1 (0.52) | ADRB1HTR6HTR3EHTR3BHTR3A | |
| SCHEMBL4490934 | 0.75 | POLB (0.46) | ADRB1HTR6CHRM1DRD2DRD4 | |
| SCHEMBL4486014 | 0.75 | POLB (0.57) | ADRB1HTR6CHRM1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603880-B1 | QUINOLINONE/BENZOXAZINONE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | claimed |