Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700724 | 0.89 | PDE3B (0.49) | PDE3BPDE3ASMN1; SMN2ALOX5PTGES | |
| SCHEMBL4703141 | 0.89 | ALOX5 (0.49) | PDE3BPDE3ASMN1; SMN2KDM5AKDM5B | |
| SCHEMBL4789580 | 0.87 | PDE3B (0.47) | PDE3BPDE3ASMN1; SMN2ALOX5PTGES | |
| SCHEMBL5309383 | 0.86 | PDE3B (0.46) | PDE3BPDE3ASMN1; SMN2KDM5AKDM5B | |
| SCHEMBL5309082 | 0.80 | KDM5A (0.58) | KDM5AKDM5BGABRA1GABRB1GABRA3 | |
| SCHEMBL4700777 | 0.79 | PDE3B (0.47) | PDE3BPDE3ASMN1; SMN2ALOX5PTGES | |
| SCHEMBL6201222 | 0.79 | KDM5A (0.50) | KDM5AKDM5BALOX5PTGESALDH1A1 | |
| SCHEMBL18584316 | 0.76 | MAP3K5 (0.55) | PDE3BPDE3ASMN1; SMN2KDM5AKDM5B | |
| SCHEMBL8895528 | 0.76 | GRIN2D (0.48) | ALDH1A1KDM4E | |
| SCHEMBL5500146 | 0.74 | KDM5A (0.44) | KDM5AKDM5BALOX5PTGESALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996553-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | Avanir Pharmaceuticals (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109251-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-09-27 | — | — | WO | disclosed |