Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700777 | 0.90 | PDE3B (0.47) | ALOX5PDE3BPDE3ASMN1; SMN2PTGES | |
| SCHEMBL4697265 | 0.89 | PDE3B (0.51) | ALOX5PDE3BPDE3ASMN1; SMN2PTGES | |
| SCHEMBL5500146 | 0.85 | KDM5A (0.44) | ALOX5PTGESKDM5AKDM5BALDH1A1 | |
| SCHEMBL5309383 | 0.84 | PDE3B (0.46) | ALOX5PDE3BPDE3ASMN1; SMN2KDM5A | |
| SCHEMBL5312523 | 0.79 | KDM5A (0.42) | ALOX5KDM5AKDM5BALDH1A1GAA | |
| SCHEMBL4700724 | 0.79 | PDE3B (0.49) | ALOX5PDE3BPDE3ASMN1; SMN2PTGES | |
| SCHEMBL5312400 | 0.79 | MEN1 (0.48) | KDM4E | |
| SCHEMBL5309082 | 0.78 | KDM5A (0.58) | KDM5AKDM5BGABRA1GABRB1GABRA3 | |
| SCHEMBL4789580 | 0.77 | PDE3B (0.47) | ALOX5PDE3BPDE3ASMN1; SMN2PTGES | |
| SCHEMBL4698391 | 0.75 | CSF1R (0.42) | ALOX5SMN1; SMN2PTGESKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996553-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | Avanir Pharmaceuticals (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109251-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-09-27 | — | — | WO | disclosed |