Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692413 | 0.86 | HCRTR1 (0.53) | CCR5HCRTR1HCRTR2KCNH2PLA2G10 | |
| SCHEMBL4699051 | 0.85 | LMNA (0.40) | HCRTR1HCRTR2HTR7ALDH1A1LMNA | |
| SCHEMBL5237741 | 0.85 | HCRTR1 (0.44) | CCR5HCRTR1HCRTR2KCNH2PLA2G10 | |
| SCHEMBL4699432 | 0.83 | CCL5 (0.44) | CCR5HCRTR1HCRTR2HTR7ALDH1A1 | |
| SCHEMBL5238954 | 0.83 | HCRTR1 (0.43) | CCR5HCRTR1HCRTR2PLA2G10HTR7 | |
| SCHEMBL5236364 | 0.83 | HCRTR1 (0.47) | CCR5HCRTR1HCRTR2KCNH2PLA2G10 | |
| SCHEMBL5234579 | 0.82 | HCRTR1 (0.42) | HCRTR1HCRTR2KCNH2PLA2G10HTR7 | |
| SCHEMBL5237249 | 0.81 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL5231170 | 0.81 | HCRTR1 (0.52) | CCR5HCRTR1HCRTR2KCNH2PLA2G10 | |
| SCHEMBL5231850 | 0.81 | HCRTR1 (0.43) | CCR5HCRTR1HCRTR2KCNH2PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987036-A1 | HETERO-BYCYCLIC ANTIVIRAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093520-A1 | HETERO-BYCYCLIC ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |