Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 5/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698842 | 0.83 | TDP1 (0.63) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4339865 | 0.83 | TDP1 (0.63) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL698843 | 0.83 | TDP1 (0.63) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL28554116 | 0.78 | GAA (0.55) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL30988968 | 0.78 | GAA (0.55) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4174786 | 0.77 | TDP1 (0.47) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL11571551 | 0.76 | TDP1 (0.55) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL30988973 | 0.75 | TDP1 (0.48) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6250115 | 0.75 | SLC1A3 (0.60) | TDP1ADAMTS4SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL11351046 | 0.73 | MMP9 (0.71) | TDP1SLC1A3SLC1A2SLC1A1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |