Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520677 | 0.85 | MAPT (0.59) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL1520681 | 0.85 | MAPT (0.59) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL4697628 | 0.84 | MAPT (0.61) | NPC1LMNAMAPTKMT2AMEN1 | |
| Water SCHEMBL6576232 | 0.84 | MAPT (0.58) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL4699409 | 0.81 | KMT2A (0.51) | NPC1MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL7750438 | 0.81 | MAPT (0.60) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL7750442 | 0.81 | MAPT (0.60) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL13611411 | 0.81 | MAPT (0.70) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL4701029 | 0.80 | HTT (0.50) | NPC1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL15917497 | 0.79 | MAPT (0.80) | NPC1LMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309544-B1 | COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS | ACURE PHARMA AB (SE) | 2008-11-05 | — | — | EP | claimed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | claimed |
| US-7153881-B2 | Compounds acting as melanocortin receptor ligands | ACURE PHARMA AB (SE) | 2006-12-26 | — | — | US | disclosed |