Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.66 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 8/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696455 | 0.86 | NTRK1 (0.64) | NTRK1NUAK1 | |
| SCHEMBL4695215 | 0.84 | NUAK1 (0.61) | NTRK1NUAK1IGF1R | |
| SCHEMBL3705689 | 0.83 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL27709595 | 0.83 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL4696858 | 0.83 | NTRK1 (0.81) | NTRK1IGF1R | |
| SCHEMBL27689887 | 0.83 | NTRK1 (0.81) | NTRK1IGF1R | |
| SCHEMBL4696821 | 0.83 | NTRK1 (0.81) | NTRK1IGF1R | |
| SCHEMBL3812515 | 0.80 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL3772425 | 0.80 | NTRK1 (1.00) | NTRK1 | |
| SCHEMBL4697195 | 0.79 | NTRK1 (0.47) | NTRK1NUAK1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |
| CN-101119988-A | Chemical compound | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | disclosed |