Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.38 |
| ▸ | PTGES | O14684 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700777 | 0.85 | PDE3B (0.47) | CSF1RRAB9AALOX5PTGESALDH1A1 | |
| SCHEMBL4700724 | 0.77 | PDE3B (0.49) | CSF1RRAB9AALOX5PTGESALDH1A1 | |
| SCHEMBL4703141 | 0.75 | ALOX5 (0.49) | ALOX5PTGESALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4856086 | 0.71 | DAO (0.45) | CSF1RPTGESALDH1A1KDM4EKDM5A | |
| SCHEMBL4751504 | 0.71 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4ES1PR3 | |
| SCHEMBL1055294 | 0.71 | KDM5A (0.49) | CSF1RRAB9AALOX5POLBALDH1A1 | |
| SCHEMBL1057337 | 0.71 | CSF1R (0.56) | CSF1RALOX5POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4699400 | 0.71 | CSF1R (0.53) | CSF1RALOX5PTGESPOLBALDH1A1 | |
| SCHEMBL5500146 | 0.70 | KDM5A (0.44) | ALOX5PTGESALDH1A1MEN1KMT2A | |
| SCHEMBL1061379 | 0.68 | KDM4E (0.64) | CSF1RRAB9AALOX5POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996553-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | Avanir Pharmaceuticals (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109251-A2 | TUMOR NECROSIS FACTOR ALPHA INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-09-27 | — | — | WO | disclosed |