Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702623 | 0.92 | CRHR1 (0.48) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4703705 | 0.89 | CRHR1 (0.55) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4702266 | 0.85 | CRHR1 (0.46) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4698530 | 0.83 | CRHR1 (0.42) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4700529 | 0.82 | CRHR1 (0.41) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4697895 | 0.82 | CRHR1 (0.42) | CRHR1LMNAMAPK1 | |
| Trifluoroacetic Acid SCHEMBL4702926 | 0.81 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL4702269 | 0.81 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL4701741 | 0.78 | CRHR1 (0.60) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4700017 | 0.77 | CRHR1 (0.59) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| EP-1569911-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | claimed |
| WO-2004050634-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | claimed |
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | disclosed |
| EP-1569911-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004050634-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |