Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700550 | 0.92 | CRHR1 (0.48) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4698530 | 0.87 | CRHR1 (0.42) | CRHR1TRPM8 | |
| Trifluoroacetic Acid SCHEMBL4703705 | 0.86 | CRHR1 (0.55) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4697895 | 0.83 | CRHR1 (0.42) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4698436 | 0.82 | CRHR1 (0.44) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4702926 | 0.81 | CRHR1 (0.55) | CRHR1 | |
| Trifluoroacetic Acid SCHEMBL4702266 | 0.81 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL4701741 | 0.78 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL4757559 | 0.78 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL4702269 | 0.78 | CRHR1 (0.64) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| EP-1569911-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | claimed |
| WO-2004050634-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | claimed |
| EP-1971580-A1 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION | BASF SE (DE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1971581-A1 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION | BASF SE (DE) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077201-A9 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION | BASF SE (DE) | 2008-07-31 | — | — | WO | disclosed |
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007077247-A1 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION | BASF SE (DE) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077201-A1 | PIPERAZINE COMPOUNDS WITH A HERBICIDAL ACTION | BASF SE (DE) | 2007-07-12 | — | — | WO | disclosed |