Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703868 | 0.92 | THRB (0.44) | HCAR3THRBHPGDHSD17B10DRD3 | |
| SCHEMBL4702408 | 0.90 | THRB (0.44) | HCAR3THRBHPGDHSD17B10DRD3 | |
| SCHEMBL5812811 | 0.86 | THRB (0.46) | HCAR3THRBHPGDHSD17B10RXRA | |
| SCHEMBL4703168 | 0.84 | THRB (0.48) | HCAR3THRBHPGDHSD17B10DRD3 | |
| SCHEMBL4698571 | 0.84 | THRB (0.41) | THRBHPGDHSD17B10LMNAL3MBTL1 | |
| SCHEMBL4703390 | 0.82 | THRB (0.46) | HCAR3THRBHPGDHSD17B10DRD3 | |
| SCHEMBL4703871 | 0.82 | THRB (0.44) | THRBHPGDHSD17B10LMNAL3MBTL1 | |
| SCHEMBL5779164 | 0.82 | CRBN (0.45) | THRBHSD17B10DRD3PTGER4MAPT | |
| SCHEMBL5781185 | 0.81 | THRB (0.48) | HCAR3THRBHPGDHSD17B10PTGER4 | |
| SCHEMBL5779552 | 0.80 | HPGD (0.44) | THRBHPGDHSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615896-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2008-04-23 | — | — | EP | claimed |