Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703871 | 0.92 | THRB (0.44) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4699188 | 0.90 | THRB (0.42) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4702409 | 0.89 | THRB (0.44) | THRBHPGDHSD17B10SMN1; SMN2POLB | |
| SCHEMBL4701536 | 0.88 | THRB (0.43) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4698515 | 0.87 | HPGD (0.44) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4699907 | 0.87 | CRBN (0.44) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4698564 | 0.85 | THRB (0.42) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4698489 | 0.85 | HPGD (0.43) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4698566 | 0.84 | HCAR3 (0.42) | THRBHPGDHSD17B10SIRT2SIRT1 | |
| SCHEMBL4702405 | 0.83 | THRB (0.45) | THRBHPGDHSD17B10SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615896-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2008-04-23 | — | — | EP | claimed |