Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991233 | 0.89 | POLB (0.55) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL15932258 | 0.87 | POLB (0.59) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL23561209 | 0.85 | ALDH1A1 (0.53) | POLBSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL9405372 | 0.85 | POLB (0.73) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL953403 | 0.81 | SMN1; SMN2 (0.59) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL5594520 | 0.78 | POLB (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL5594524 | 0.78 | POLB (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL14590615 | 0.78 | POLB (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL12871784 | 0.78 | HRH3 (0.43) | POLBSMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL27826063 | 0.78 | SMN1; SMN2 (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966187-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071952-A1 | PIPERAZINE COMPOUNDS USEFUL AS ANTAGONISTS OF C-C CHEMOKINES (CCR2B AND CCR5) FOR THE TREATMENT OF INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |