Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 6/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700129 | 0.88 | LMNA (0.51) | LMNAPARP1TAS1R3TAS1R1HDAC8 | |
| SCHEMBL4702603 | 0.85 | LMNA (0.60) | LMNAHTTNPSR1PARP1AR | |
| SCHEMBL4698475 | 0.82 | LMNA (0.58) | LMNAHTTNPSR1PARP1AR | |
| SCHEMBL4701092 | 0.82 | LMNA (0.60) | LMNAHTTNPSR1PARP1AR | |
| SCHEMBL4700395 | 0.79 | LMNA (0.53) | LMNAHTTNPSR1PARP1AR | |
| SCHEMBL4704345 | 0.79 | PARP1 (0.58) | PARP1 | |
| SCHEMBL4699704 | 0.78 | HTT (0.53) | LMNAHTTNPSR1PARP1KMT2A | |
| SCHEMBL4697638 | 0.78 | PARP1 (0.48) | PARP1ENPP1 | |
| SCHEMBL4702676 | 0.78 | PARP1 (0.48) | PARP1TAS1R3TAS1R1HDAC8ENPP1 | |
| SCHEMBL4697402 | 0.78 | PARP1 (0.57) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427708-B1 | AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2008-09-10 | — | — | EP | claimed |