Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 13/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697638 | 0.88 | PARP1 (0.48) | PARP1ENPP1HDAC1 | |
| SCHEMBL4702676 | 0.88 | PARP1 (0.48) | PARP1ENPP1TAS1R3TAS1R1HDAC3 | |
| SCHEMBL4699173 | 0.88 | LMNA (0.55) | LMNAPARP1ENPP1TAS1R3TAS1R1 | |
| SCHEMBL4701253 | 0.85 | PARP1 (0.64) | LMNAPARP1ENPP1 | |
| SCHEMBL4704345 | 0.85 | PARP1 (0.58) | PARP1 | |
| SCHEMBL4697402 | 0.84 | PARP1 (0.57) | PARP1 | |
| SCHEMBL4700486 | 0.81 | PARP1 (0.49) | PARP1ENPP1 | |
| SCHEMBL4702672 | 0.81 | LMNA (0.54) | LMNAPARP1ENPP1 | |
| SCHEMBL4699679 | 0.80 | LMNA (0.55) | LMNAPARP1ENPP1 | |
| SCHEMBL4698543 | 0.78 | PARP1 (0.52) | LMNAPARP1ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427708-B1 | AMINO-PHTHALAZINONE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2008-09-10 | — | — | EP | claimed |