Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4700511 | 0.99 | OPRL1 (0.49) | OPRL1OPRM1HSD11B1KDM4EBRD4 | |
| SCHEMBL4698863 | 0.90 | OPRL1 (0.47) | OPRL1OPRM1HSD11B1KDM4EBRD4 | |
| SCHEMBL4697898 | 0.90 | HSD11B1 (0.53) | OPRL1OPRM1HSD11B1HTR2AHTR7 | |
| SCHEMBL4698021 | 0.89 | MTNR1A (0.46) | OPRL1OPRM1HSD11B1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL4701916 | 0.89 | OPRL1 (0.47) | OPRL1OPRM1HSD11B1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL4703646 | 0.89 | OPRM1 (0.53) | OPRL1OPRM1HSD11B1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL4699313 | 0.89 | MTNR1A (0.45) | OPRL1OPRM1HSD11B1HTR2AHTR7 | |
| SCHEMBL4702244 | 0.87 | HSD11B1 (0.47) | OPRL1OPRM1HSD11B1KDM4EBRD4 | |
| SCHEMBL2785350 | 0.86 | HSD11B1 (0.56) | OPRL1OPRM1HSD11B1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL2780210 | 0.85 | HSD11B1 (0.56) | OPRL1OPRM1HSD11B1KDM4EBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | claimed |
| EP-1560823-B1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | GRUENENTHAL GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| EP-1560823-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043949-A1 | 4-SUBSTITUTED 1-AMINOCYCLOHEXANE DERIVATIVES FOR UTILIZATION AS ORL1-RECEPTOR AND MU-OPIATE RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |