Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.69 |
| ▸ | JAK2 | O60674 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699249 | 0.84 | HTR6 (0.60) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4700533 | 0.83 | HTR6 (0.59) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| SCHEMBL4702019 | 0.83 | HTR6 (0.67) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4697947 | 0.82 | HTR6 (0.66) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| SCHEMBL5820238 | 0.81 | PKM (0.53) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| SCHEMBL4700089 | 0.77 | POLB (0.56) | ALDH1A1MCOLN3L3MBTL1MAPK1KMT2A | |
| SCHEMBL4698210 | 0.76 | PKM (0.48) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 | |
| SCHEMBL14459524 | 0.75 | KMT2A (0.65) | PKMALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL4700085 | 0.75 | TSHR (0.51) | PKMALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL5757786 | 0.73 | LMNA (0.45) | PKMJAK2ALDH1A1MCOLN3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660483-B1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LTD (GB) | 2008-12-24 | — | — | EP | disclosed |
| US-20080275040-A1 | 8-(1-Piperazinyl)-Quinoline Derivatives and Their Use in the Treatment of Cns Disorders | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| EP-1660483-A1 | 8-(1-PIPERAZINYL)-QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021530-A1 | 8- (1-PIPERAZINYL)- QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275040-A1 | 8-(1-Piperazinyl)-Quinoline Derivatives and Their Use in the Treatment of Cns Disorders | PMP22, AQP4, SLC18A2 | PKM 1968/4885JAK2 2281/4885ALDH1A1 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.