Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ARG1 | P05089 | 4/20 | 0.41 |
| ▸ | ARG2 | P78540 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3522567 | 0.91 | CPB2 (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL4700418 | 0.82 | L3MBTL1 (0.58) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL5616394 | 0.82 | CYP1A2 (0.47) | CYP1A2MAPK1SMN1; SMN2CPB2HRH3 | |
| Trifluoroacetic Acid SCHEMBL16700590 | 0.81 | KDM4E (0.48) | CYP1A2MAPK1SMN1; SMN2CPB2HRH3 | |
| SCHEMBL378444 | 0.80 | HRH3 (0.65) | CYP1A2MAPK1SMN1; SMN2HRH3SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL16701135 | 0.80 | CYP1A2 (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL3749229 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2ARG1ARG2 | |
| Trifluoroacetic Acid SCHEMBL28941864 | 0.79 | HRH3 (0.50) | CYP1A2MAPK1SMN1; SMN2CPB2HRH3 | |
| Trifluoroacetic Acid SCHEMBL21994721 | 0.78 | CYP1A2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL21994719 | 0.78 | CYP1A2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | claimed |
| EP-1926737-B1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-15 | — | — | EP | disclosed |
| EP-1926737-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031428-A1 | 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | WO | disclosed |
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BARTKOVITZ DAVID J | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060607-A1 | 4-amino-thieno[3,2-c] pyridine-7-carboxylic acid derivatives | BRAF, RAF1, MAP3K7 | CHRM2 4372/4885CHRM4 4689/4885CHRM5 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.