Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589062 | 0.86 | PDE3B (0.55) | HDAC3KDM4EHTTALOX15ALOX5 | |
| SCHEMBL359850 | 0.86 | ALOX15 (0.58) | HDAC3KDM4ENPC1PKMNFKB1 | |
| SCHEMBL27876767 | 0.83 | HDAC3 (0.54) | HDAC3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3592304 | 0.82 | L3MBTL1 (0.52) | KDM4ENPC1PKMNFKB1RAB9A | |
| SCHEMBL27650579 | 0.82 | PDE3B (0.51) | HDAC3KDM4ESMN1; SMN2HTTALOX15 | |
| Propionic Acid SCHEMBL27755022 | 0.82 | HDAC3 (0.48) | HDAC3NPC1SMN1; SMN2HTTALOX15 | |
| SCHEMBL25139422 | 0.81 | HDAC3 (0.55) | HDAC3NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL24814483 | 0.81 | HDAC3 (0.58) | HDAC3KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26068233 | 0.81 | MAOB (0.52) | KDM4ENPC1PKMNFKB1RAB9A | |
| SCHEMBL3595128 | 0.80 | MAOB (0.51) | KDM4ENPC1PKMNFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |