Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GLS | O94925 | 2/20 | 0.51 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341489 | 0.88 | RAB9A (0.55) | ALOX15HTTHDAC3ALDH1A1NPC1 | |
| SCHEMBL22919854 | 0.86 | ALOX15 (0.56) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL4701042 | 0.86 | HDAC3 (0.52) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL27876767 | 0.85 | HDAC3 (0.54) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL24814483 | 0.83 | HDAC3 (0.58) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL22787740 | 0.82 | ALOX15 (0.51) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL2494979 | 0.81 | ECE2 (0.54) | ALDH1A1ANO1NPC1MAPTMEN1 | |
| SCHEMBL29440893 | 0.81 | HDAC3 (0.59) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| SCHEMBL1163335 | 0.81 | HDAC3 (0.59) | ALOX15HTTHDAC3PLK1ALDH1A1 | |
| Propionic Acid SCHEMBL27755022 | 0.81 | HDAC3 (0.48) | ALOX15HTTHDAC3PLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3703692-B1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-07-23 | — | — | EP | disclosed |
| US-12275729-B2 | Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-04-15 | — | — | US | disclosed |
| US-12157727-B2 | Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-12-03 | — | — | US | disclosed |
| US-RE49934-E1 | Inhibitors of cellular metabolic processes | SERVIER PHARMACEUTICALS LLC (US) | 2024-04-23 | — | — | US | disclosed |
| CN-117510470-A | Pyridazinone compounds and application thereof | 暨南大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-109890822-B | Inhibitors of cellular metabolic processes | 安吉奥斯医药品有限公司 | 2022-08-30 | — | — | CN | disclosed |
| US-20220235028-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-07-28 | — | — | US | disclosed |
| US-11325914-B1 | Inhibitors of cellular metabolic processes | SERVIER PHARMACEUTICALS LLC (US) | 2022-05-10 | — | — | US | disclosed |
| US-11325914-B1 | Inhibitors of cellular metabolic processes | SERVIER PHARMACEUTICALS LLC (US) | 2022-05-10 | — | — | US | disclosed |
| EP-3982959-A2 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2008008539-A2 | FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR | AMGEN INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2007138472-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007138472-A2 | TRIAZOLOPYRIDAZINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-12-06 | — | — | WO | disclosed |
| US-20070203136-A1 | TRIAZOLOPYRIDAZINES AS KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-08-30 | — | — | US | disclosed |
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |
| EP-1347978-B1 | NOVEL SUBSTITUTED IMIDAZOTRIAZINONES AS PDE II-INHIBITORS | BAYER HEALTHCARE AG (DE) | 2005-08-31 | — | — | EP | disclosed |
| EP-1347978-A1 | NOVEL SUBSTITUTED IMIDAZOTRIAZINONES AS PDE II-INHIBITORS | Bayer Aktiengesellschaft (DE) | 2003-10-01 | — | — | EP | disclosed |
| US-6573263-B2 | For improving perception, concentration power, learning power and/ or memory power | BAYER AKTIENGESELLSCHAFT (DE) | 2003-06-03 | — | — | US | disclosed |
| US-20020198377-A1 | Substituted imidazotriazinones | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-26 | — | — | US | disclosed |
| WO-2002050078-A1 | NOVEL SUBSTITUTED IMIDAZOTRIAZINONES AS PDE II-INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203136-A1 | TRIAZOLOPYRIDAZINES AS KINASE MODULATORS | RET, MET, ABL1 | ALOX15 4241/4885HTT 3089/4885HDAC3 2575/4885 |
| US-12157727-B2 | Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | IDO1, IDO2, INMT | ALOX15 1049/4885HTT 300/4885HDAC3 192/4885 |
| US-20020198377-A1 | Substituted imidazotriazinones | CAMK4, ITPR1, KCNJ5 | ALOX15 3720/4885HTT 1142/4885HDAC3 3592/4885 |
| US-20220235028-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | ALOX15 1034/4885HTT 358/4885HDAC3 182/4885 |
| US-12275729-B2 | Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | IDO1, IDO2, INMT | ALOX15 1068/4885HTT 336/4885HDAC3 177/4885 |
| US-11325914-B1 | Inhibitors of cellular metabolic processes | MNAT1, MAT2A, PCK2 | ALOX15 4229/4885HTT 2791/4885HDAC3 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.