SCHEMBL4701131

SCHEMBL4701131

C[Si](C)(C)CCOCOc1cnccc1F

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 4/20 0.42
FEN1 P39748 4/20 0.42
MAPT P10636 1/20 0.31
DGAT1 O75907 2/20 0.31
PDE10A Q9Y233 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4705428 0.82 ALOX5AP (0.35) ALOX5APFEN1MAPT
SCHEMBL14159684 0.81 CA12 (0.37) LOXL2
SCHEMBL4698645 0.81 CA12 (0.42) ALOX5APFEN1MAPT
SCHEMBL16012024 0.79 ALOX5AP (0.35) ALOX5APFEN1MAPTDGAT1
SCHEMBL4790874 0.79 ALOX5AP (0.40) ALOX5APFEN1MAPT
SCHEMBL4857523 0.78 ALDH1A1 (0.36) ALOX5APFEN1MAPT
SCHEMBL26648940 0.74 ALOX5AP (0.41) ALOX5APFEN1DGAT1PDE10A
SCHEMBL5514200 0.74 ALOX5AP (0.46) ALOX5APFEN1DGAT1
SCHEMBL30712019 0.74 ALOX5AP (0.41) ALOX5APFEN1DGAT1
SCHEMBL4790895 0.73 RAB9A (0.38) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1486489-B1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation DOW AGROSCIENCES LLC (US) 2016-04-27 EP disclosed
EP-1204643-B1 FUNGICIDAL HETEROCYCLIC AROMATIC AMIDES AND THEIR COMPOSITIONS, METHODS OF USE AND PREPARATION DOW AGROSCIENCES LLC (US) 2008-06-04 EP disclosed
US-RE39991-E1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation DOW AGROSCIENCES LLC (US) 2008-01-01 US disclosed
US-RE39991-E1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation DOW AGROSCIENCES LLC (US) 2008-01-01 US disclosed
US-7034035-B2 Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation DOW AGROSCIENCES LLC (US) 2006-04-25 US disclosed
US-20050250667-A1 Effervescent granulated composition GIVAUDAN SA (CH) 2005-11-10 US disclosed
US-6927225-B2 Fungicidal 2-pyridyl alkyl amides and their compositions, methods of use and preparation DOW AGROSCIENCES LLC (US) 2005-08-09 US disclosed
EP-1516875-A1 FUNGICIDAL HETEROCYCLIC AROMATIC AMIDES AND THEIR COMPOSITIONS, METHODS OF USE AND PREPARATION Dow AgroSciences LLC (US) 2005-03-23 EP disclosed
EP-1516874-A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Dow AgroSciences LLC (US) 2005-03-23 EP disclosed
EP-1493733-A2 Fungicidal heterocyclic aromatic amides, their compositions and methods of use Dow AgroSciences LLC (US) 2005-01-05 EP disclosed
US-20030018012-A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation RICKS MICHAEL J (US) 2003-01-23 US disclosed
US-20020177578-A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation RICKS MICHAEL J (US) 2002-11-28 US disclosed
EP-1234823-A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Dow AgroSciences LLC (US) 2002-08-28 EP disclosed
EP-1234825-A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Dow AgroSciences LLC (US) 2002-08-28 EP disclosed
EP-1234826-A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Dow AgroSciences LLC (US) 2002-08-28 EP disclosed
EP-1234827-A2 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation Dow AgroSciences LLC (US) 2002-08-28 EP disclosed
US-6355660-B1 HETEROCYCLIC FUNGICIDES SUBSTITUTED WITH AMIDE GROUPS DOW AGROSCIENCES LLC 2002-03-12 US disclosed
US-4822596-A MOISTURE ABSORBING POLYMERS IN NONAQUEOUS LIQUID; FOR AEROSOL SPRAYING LEVER BROTHERS COMPANY (US) 1989-04-18 US disclosed
US-4743440-A ANTIPERSPIRANTS, WATER ABSORBING POLYMER LEVER BROTHERS COMPANY (US) 1988-05-10 US disclosed
US-4650670-A MOISTURE-ABSORBENT POLYMER LEVER BROTHERS COMPANY (US) 1987-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030018012-A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation CYP4X1, CYP1A1, NAT1 ALOX5AP 3384/4885FEN1 2050/4885MAPT 1746/4885
US-20020177578-A1 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation CYP4X1, CYP1A1, NAT1 ALOX5AP 3384/4885FEN1 2050/4885MAPT 1746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.