SCHEMBL470127

SCHEMBL470127

Bc1ccc(OC2CC2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.43
PARP10 Q53GL7 1/20 0.42
HRH3 Q9Y5N1 3/20 0.39
PTPN1 P18031 1/20 0.39
SLC6A4 P31645 4/20 0.38
SLC6A2 P23975 2/20 0.38
SLC6A3 Q01959 2/20 0.38
EPHX2 P34913 4/20 0.38
ALDH1A1 P00352 1/20 0.37
TSHR P16473 1/20 0.37
MAP4K4 O95819 1/20 0.37
FURIN P09958 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36
CHRNA4 P43681 1/20 0.36
CHRNA10 Q9GZZ6 1/20 0.36
CHRNA9 Q9UGM1 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10187268 0.91 PARP10 (0.48) HRH1PARP10HRH3EPHX2ALDH1A1
SCHEMBL12260856 0.89 PARP10 (0.47) HRH1PARP10HRH3EPHX2ALDH1A1
SCHEMBL18620969 0.85 HRH1 (0.66) HRH1HRH3SLC6A2SLC6A3CHRNB2
SCHEMBL20686997 0.78 CHRNB2 (0.53) HRH1SLC6A2MAP4K4CHRNB2CHRNA4
SCHEMBL6903727 0.77 TDP1 (0.50) HRH1PARP10HRH3PTPN1SLC6A4
SCHEMBL19154836 0.76 HRH3 (0.53) HRH3SMN1; SMN2
SCHEMBL7943168 0.75 HRH1 (0.43) HRH1PARP10HRH3PTPN1SLC6A4
SCHEMBL16838744 0.75 SMN1; SMN2 (0.56) HRH1PARP10HRH3EPHX2ALDH1A1
SCHEMBL9572108 0.75 EPHX2 (0.57) HRH1PARP10EPHX2
SCHEMBL9641576 0.75 HRH1 (0.43) HRH1PARP10HRH3PTPN1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012032014-A1 ETHYNE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-03-15 WO disclosed
WO-2012001107-A1 PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-01-05 WO disclosed