Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 7/20 | 0.48 |
| ▸ | PLD2 | O14939 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703878 | 0.93 | BDKRB1 (0.44) | BDKRB1HPGD | |
| SCHEMBL4705843 | 0.92 | BDKRB1 (0.44) | BDKRB1PLD2PLD1HPGD | |
| SCHEMBL4704254 | 0.90 | BDKRB1 (0.47) | BDKRB1PLD2PLD1MEN1KMT2A | |
| SCHEMBL6045893 | 0.89 | BDKRB1 (0.52) | BDKRB1PLD2PLD1MEN1KMT2A | |
| SCHEMBL4703557 | 0.88 | BDKRB1 (0.49) | BDKRB1KMT2A | |
| SCHEMBL4789617 | 0.86 | ACHE (0.44) | BDKRB1MCHR1 | |
| SCHEMBL4705015 | 0.86 | HTT (0.51) | — | |
| SCHEMBL4790458 | 0.86 | BDKRB1 (0.45) | BDKRB1PLD2PLD1 | |
| SCHEMBL4790592 | 0.84 | BDKRB1 (0.68) | BDKRB1MEN1KMT2A | |
| SCHEMBL4703795 | 0.83 | BDKRB1 (0.41) | BDKRB1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |