Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 13/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6046052 | 0.89 | BDKRB1 (0.49) | BDKRB1PLD2PLD1 | |
| SCHEMBL4702492 | 0.88 | BDKRB1 (0.52) | BDKRB1 | |
| SCHEMBL4704254 | 0.88 | BDKRB1 (0.47) | BDKRB1PLD2PLD1 | |
| SCHEMBL4705843 | 0.87 | BDKRB1 (0.44) | BDKRB1PLD2PLD1 | |
| SCHEMBL4703557 | 0.86 | BDKRB1 (0.49) | BDKRB1DRD3 | |
| SCHEMBL4703878 | 0.86 | BDKRB1 (0.44) | BDKRB1MAPK1 | |
| SCHEMBL4701432 | 0.86 | BDKRB1 (0.48) | BDKRB1PLD2PLD1 | |
| SCHEMBL4789665 | 0.85 | BDKRB1 (0.53) | BDKRB1 | |
| SCHEMBL4789617 | 0.85 | ACHE (0.44) | BDKRB1 | |
| SCHEMBL4705015 | 0.85 | HTT (0.51) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |