Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | BCL3 | P20749 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702407 | 0.95 | BCL3 (0.47) | HTTBCL3ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL4705843 | 0.92 | BDKRB1 (0.44) | HTTSMN1; SMN2 | |
| SCHEMBL4703878 | 0.91 | BDKRB1 (0.44) | HTTALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4703557 | 0.91 | BDKRB1 (0.49) | HTT | |
| SCHEMBL4789617 | 0.90 | ACHE (0.44) | MAPT | |
| SCHEMBL4702492 | 0.88 | BDKRB1 (0.52) | — | |
| SCHEMBL4704254 | 0.88 | BDKRB1 (0.47) | HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6046003 | 0.88 | HTT (0.56) | HTTBCL3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4701432 | 0.86 | BDKRB1 (0.48) | — | |
| SCHEMBL4790458 | 0.85 | BDKRB1 (0.45) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |