Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386238 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6386400 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6385238 | 0.95 | ALDH1A1 (0.43) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6391808 | 0.94 | ALDH1A1 (0.41) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6385743 | 0.92 | ALDH1A1 (0.41) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6389727 | 0.92 | ALDH1A1 (0.41) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6387583 | 0.92 | ALDH1A1 (0.48) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6385891 | 0.90 | ALDH1A1 (0.40) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6385898 | 0.90 | ALDH1A1 (0.40) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6385257 | 0.87 | ALDH1A1 (0.44) | ALDH1A1MAPK1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | claimed |
| EP-1458684-A2 | THERAPEUTIC HETEROCYCLES | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051276-A2 | THERAPEUTIC HETEROCYCLES | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | claimed |
| EP-1458684-B1 | THERAPEUTIC HETEROCYCLES AS BRADYKININ B2 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |
| US-20050245503-A1 | Therapeutic heterocycles | ASTRAZENECA AB (SE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245503-A1 | Therapeutic heterocycles | OPRK1, RECQL, OPRM1 | ALDH1A1 2117/4885MAPK1 3804/4885KMT2A 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.