Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193867 | 0.89 | ALDH1A1 (0.56) | ABCB1ABCC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL311157 | 0.89 | ALDH1A1 (0.56) | ABCB1ABCC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29791349 | 0.82 | ALDH1A1 (0.56) | L3MBTL1ABCB1ABCC1LMNAALDH1A1 | |
| SCHEMBL309983 | 0.82 | ALDH1A1 (0.56) | L3MBTL1ABCB1ABCC1LMNAALDH1A1 | |
| SCHEMBL46705 | 0.81 | TTR (0.47) | L3MBTL1TTRABCB1ABCC1LMNA | |
| SCHEMBL10363811 | 0.79 | TTR (0.67) | L3MBTL1TTRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL205073 | 0.79 | S100A4 (0.51) | L3MBTL1ABCB1ABCC1LMNAALDH1A1 | |
| SCHEMBL23421733 | 0.78 | ALDH1A1 (0.45) | ABCB1ABCC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1068743 | 0.76 | SMN1; SMN2 (0.50) | ABCB1ABCC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1128860 | 0.76 | HPSE (0.56) | TTRLMNAALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003642-A1 | FUSED TRICYCLIC COMPOUNDS AND USE THEREOF FOR TREATING VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-01-12 | — | — | WO | disclosed |