Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47017 | 0.81 | L3MBTL1 (0.55) | TTRL3MBTL1ABCB1ABCC1SMN1; SMN2 | |
| SCHEMBL7524 | 0.79 | HPGD (0.62) | ALOX15MAPK1HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL31572456 | 0.79 | HPGD (0.62) | ALOX15MAPK1HSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL347489 | 0.79 | ALOX15 (0.66) | ALOX15ALOX12MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL30688242 | 0.79 | ALOX15 (0.66) | ALOX15ALOX12MAPK1L3MBTL1SMN1; SMN2 | |
| Hydrogen Sulfide SCHEMBL28313840 | 0.78 | HPGD (0.60) | ALOX15MAPK1HSD17B10L3MBTL1ABCB1 | |
| SCHEMBL27515978 | 0.77 | HSPB1 (0.49) | ALOX15ALOX12MAPK1SMN1; SMN2MAPT | |
| SCHEMBL1128860 | 0.76 | HPSE (0.56) | TTRSMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL20160408 | 0.76 | HSPB1 (0.72) | L3MBTL1MAPTMEN1KMT2AHTT | |
| SCHEMBL8075197 | 0.76 | HPSE (0.55) | TTRMAPK1L3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003642-A1 | FUSED TRICYCLIC COMPOUNDS AND USE THEREOF FOR TREATING VIRAL DISEASES | MERCK SHARP & DOHME CORP. (US) | 2012-01-12 | — | — | WO | disclosed |