Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL990169 | 0.93 | ABCB11 (0.33) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL22108953 | 0.81 | ALOX5AP (0.32) | — | |
| SCHEMBL22108951 | 0.79 | NAAA (0.34) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL21386576 | 0.79 | NAAA (0.34) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL624867 | 0.74 | CYP3A4 (0.38) | ALDH1A1CYP3A4HPGDTDP1 | |
| SCHEMBL28232289 | 0.74 | — | — | |
| SCHEMBL28371956 | 0.74 | ESR1 (0.37) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL3972524 | 0.74 | IDO1 (0.34) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL30298623 | 0.74 | HTR2B (0.33) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 | |
| SCHEMBL6596126 | 0.74 | HTR2B (0.33) | ABCB11ALDH1A1NR3C1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981892-A1 | THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS | UCB Pharma, S.A. (BE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007088345-A1 | THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS | UCB PHARMA S.A. (BE) | 2007-08-09 | — | — | WO | disclosed |