Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704279 | 0.88 | KDM2B (0.48) | TMEM97SIGMAR1HTR1AHTR2ADRD2 | |
| SCHEMBL4222884 | 0.84 | TMEM97 (0.51) | TMEM97SIGMAR1HTR1AHTR2ADRD2 | |
| SCHEMBL4050942 | 0.80 | GRIN1 (0.51) | HTR2ADRD2DRD3DRD4GRIN1 | |
| SCHEMBL4758750 | 0.80 | DRD2 (0.48) | TMEM97SIGMAR1HTR1AHTR2ADRD2 | |
| SCHEMBL4048748 | 0.79 | DRD2 (0.49) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL4046264 | 0.77 | HTR2A (0.48) | TMEM97SIGMAR1HTR1AHTR2ADRD2 | |
| SCHEMBL4049636 | 0.77 | MEN1 (0.46) | TMEM97SIGMAR1HTR1AHTR2ADRD2 | |
| SCHEMBL4048984 | 0.77 | ALDH1A1 (0.48) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL4048988 | 0.77 | ALDH1A1 (0.48) | HTR1AHTR2ADRD2DRD3DRD4 | |
| SCHEMBL4224500 | 0.77 | DRD2 (0.48) | TMEM97SIGMAR1HTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-B1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2008-11-26 | — | — | EP | claimed |