Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048748 | 0.88 | DRD2 (0.49) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4224500 | 0.87 | DRD2 (0.48) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4705658 | 0.83 | DRD2 (0.53) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4045253 | 0.82 | ALDH1A1 (0.49) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4051310 | 0.82 | ALDH1A1 (0.51) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4054675 | 0.82 | CHRNB4 (0.53) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4222884 | 0.82 | TMEM97 (0.51) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4051698 | 0.81 | ALDH1A1 (0.50) | DRD2DRD3HTR2AHTR1AALDH1A1 | |
| SCHEMBL4046282 | 0.81 | ALDH1A1 (0.50) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL4046988 | 0.81 | DRD2 (0.47) | DRD2DRD3DRD4HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-B1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2008-11-26 | — | — | EP | claimed |