Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 10/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703202 | 0.89 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CYP2C19F10F2 | |
| SCHEMBL4702318 | 0.84 | F10 (0.41) | ALDH1A1F10F2KLKB1 | |
| Hydrochloric Acid SCHEMBL4705964 | 0.81 | ALDH1A1 (0.61) | ALDH1A1CYP3A4CYP2C19KMT2AMEN1 | |
| SCHEMBL4706167 | 0.81 | KDM1A (0.51) | CYP3A4CYP2C19F10KMT2AMEN1 | |
| SCHEMBL4495030 | 0.80 | F10 (0.57) | F10F2KLKB1 | |
| SCHEMBL4702811 | 0.78 | ALDH1A1 (0.48) | ALDH1A1F10F2KLKB1 | |
| SCHEMBL4704214 | 0.78 | F10 (0.41) | F10F2KLKB1 | |
| SCHEMBL4702122 | 0.77 | F10 (0.41) | F10F2KLKB1 | |
| SCHEMBL4705534 | 0.77 | F10 (0.43) | ALDH1A1CYP3A4CYP2C19F10F2 | |
| SCHEMBL4705662 | 0.76 | F10 (0.40) | F10F2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567489-B1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LTD (GB) | 2008-07-23 | — | — | EP | disclosed |
| US-20060166985-A1 | Pyrrolydin-2-one derivatives as inhibitors of thrombin and factor xa | GLAXO GROUP LIMITED (GB) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166985-A1 | Pyrrolydin-2-one derivatives as inhibitors of thrombin and factor xa | TFPI, TFPI2, SERPINC1 | ALDH1A1 3827/4885CYP3A4 683/4885CYP2C19 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.