Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705725 | 0.82 | PGR (0.53) | PGRNR3C1ALDH1A1TDP1MEN1 | |
| SCHEMBL4703462 | 0.81 | PGR (0.67) | PGRNR3C1 | |
| SCHEMBL4704512 | 0.76 | PGR (0.47) | PGRNR3C1MEN1KMT2A | |
| SCHEMBL4703420 | 0.75 | NR3C1 (0.62) | PGRNR3C1 | |
| SCHEMBL4704783 | 0.71 | NR3C1 (0.60) | PGRNR3C1ALDH1A1FGFR1FGFR3 | |
| SCHEMBL4704555 | 0.64 | NR3C1 (0.51) | PGRNR3C1ALDH1A1 | |
| SCHEMBL4703771 | 0.63 | NR3C1 (0.50) | PGRNR3C1ALDH1A1 | |
| SCHEMBL4706288 | 0.62 | NR3C1 (0.48) | PGRNR3C1ALDH1A1TDP1LMNA | |
| SCHEMBL30535903 | 0.61 | ALDH1A1 (0.74) | ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL1287837 | 0.61 | ALDH1A1 (0.74) | ALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532113-B1 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2008-08-06 | — | — | EP | claimed |