Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352493 | 0.81 | POLB (0.56) | POLBALDH1A1TDP1SMN1; SMN2RAB9A | |
| SCHEMBL13947349 | 0.79 | RAB9A (0.65) | POLBALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL1694984 | 0.79 | RAB9A (0.62) | ALDH1A1LMNATDP1SMN1; SMN2RAB9A | |
| SCHEMBL6358755 | 0.78 | HTT (0.66) | P2RX7ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL7601765 | 0.78 | LMNA (0.70) | ALDH1A1GAALMNATDP1SMN1; SMN2 | |
| SCHEMBL4242979 | 0.78 | KCNA5 (0.54) | POLBALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL8722345 | 0.78 | KMT2A (0.65) | POLBALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL483578 | 0.78 | RAB9A (0.74) | POLBALDH1A1GAALMNATDP1 | |
| SCHEMBL6369514 | 0.77 | KCNA5 (0.58) | POLBALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL5418289 | 0.77 | P2RX7 (0.70) | P2RX7GAALMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458684-B1 | THERAPEUTIC HETEROCYCLES AS BRADYKININ B2 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | claimed |