Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389331 | 0.90 | MAPT (0.46) | SERPINE1NFKBIARELAEPHX2MAPT | |
| SCHEMBL4706506 | 0.82 | P2RY12 (0.42) | SERPINE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5577912 | 0.77 | CTSB (0.43) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL4704913 | 0.75 | SERPINE1 (0.40) | SERPINE1MAPTALDH1A1KMT2ACYP3A4 | |
| SCHEMBL4704963 | 0.75 | THRB (0.41) | SERPINE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4704834 | 0.72 | SERPINE1 (0.38) | SERPINE1MAPTALDH1A1KMT2AGPR119 | |
| SCHEMBL388686 | 0.71 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4706555 | 0.71 | GPR119 (0.44) | MMP2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4704377 | 0.68 | GPR119 (0.42) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL5263920 | 0.68 | GPR119 (0.62) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606282-B1 | PHENYL- AND PYRIDYLPIPEREIDINYE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | ARENA PHARM INC (US) | 2008-11-12 | — | — | EP | claimed |