SCHEMBL4703571

SCHEMBL4703571

Nc1cc(F)c(N2CC(O)(C(F)(F)F)C2)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
CFTR P13569 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5287503 0.79 SOS1 (0.31)
SCHEMBL4707905 0.76 ALDH1A1 (0.32)
SCHEMBL240685 0.74 ALDH1A1 (0.31)
SCHEMBL4704302 0.72 MAOA (0.65) CFTR
SCHEMBL18410289 0.70 LRRK2 (0.44) ALOX5APFEN1
SCHEMBL5280901 0.69 MAP3K12 (0.32)
SCHEMBL3041351 0.67 ALDH1A1 (0.37)
SCHEMBL238377 0.66 ALDH1A1 (0.43)
SCHEMBL240699 0.66 PDE9A (0.35)
SCHEMBL239854 0.66 MAPT (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1902048-A1 OXAZOLIDINONE CARBOXAMIDES CONTAINING AZETIDINE AND CYCLOBUTANE AS ANTIBACTERIAL AGENTS Pharmacia & Upjohn Company LLC (US) 2008-03-26 EP disclosed
WO-2007004037-A1 OXAZOLIDINONE CARBOXAMIDES CONTAINING AZETIDINE AND CYCLOBUTANE AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2007-01-11 WO disclosed